Packs of 10, 14, 20, 21, 28, 28 (cal), 30, 50x1, 56, 60, 98, 98 (cal), 100, 210, 250, 280 tablets, HDPE bottle pack(s): HDPE bottles with silica gel desiccant contained in the polypropylene lid containing 100 and 250 film-coated tablets, 12 . those treated with high-dose diuretics), a starting dose of 25 mg once daily should be considered (see section 4.4). The usual starting dose is 50 mg of losartan once daily. Losartan may be administered with other antihypertensive agents, especially with diuretics (e.g.hydrochlorothiazide) (see sections 4.3, 4.4, 4.5 and 5.1). Your doctor may increase your dosage to 100 mg per day if needed. In a clinical trial it was found that fluconazole (inhibitor of CYP2C9) decreases the exposure to the active metabolite by approximately 50%. There is no clear evidence that taking angiotensin receptor blockers (ARBs) like losartan will cause complications. The pharmacokinetic parameters for the metabolite differed to a greater extent between the age groups. Discontinuation of losartan in hypertensive patients did not result in an abrupt rise in blood pressure (rebound). In a clinical study conducted in type 2 diabetic patients with nephropathy, the incidence of hyperkalaemia was higher in the group treated with losartan as compared to the placebo group (see section 4.8). Adult dosage (ages 18–64 years) The typical starting dosage is 50 mg once daily. It happens rarely, but some people have serious side effects after taking losartan. Plasma clearance of losartan and its active metabolite is about 600 mL/min and 50 mL/min, respectively. A: Generally acceptable. Close menu. AUC values for losartan, its active metabolite and hydrochlorothiazide, extrapolated from data obtained with losartan administered to rats at a dose of 50 mg/kg/day in combination with 12.5 mg/kg/day of hydrochlorothiazide, were approximately 6, 2, and 2 times greater than those achieved in humans with 100 mg of losartan in combination with 25 mg of hydrochlorothiazide. other medicines to help lower your blood pressure, including aliskiren, potassium supplements or salt substitutes which contain potassium, tablets which make you pee more (diuretics), lithium (a medicine for mental health problems), spironolactone (a medicine to treat heart failure), angiotensin converting enzyme (ACE) inhibitors - for example, tablets which make you pee more (diuretics) - for example, if you're under 55 - you'll usually be offered an ACE inhibitor or an angiotensin receptor blocker, if you're 55 or older, or you're any age and of African Caribbean or black African origin - you'll usually be offered a calcium channel blocker. When pregnancy is diagnosed, treatment with losartan should be stopped immediately and, if appropriate, alternative therapy should be started. In this study 3152 patients with heart failure (NYHA Class II-IV) were followed for almost two years (median: 1.5 years) in order to determine whether losartan is superior to captopril in reducing all cause mortality. Dosage should be adjusted according to blood pressure response. Unless continued losartan therapy is considered essential, patients planning pregnancy should be changed to alternative anti-hypertensive treatments which have an established safety profile for use in pregnancy. Doses above 1.4 mg/kg (or in excess of 100 mg) daily have not been studied in paediatric patients. It is not recommended in children with glomerular filtration rate < 30 ml/ min/1.73 m2, as no data are available (see also section 4.4). Remember, by keeping your blood pressure low, you're protecting yourself against having a heart attack or stroke in the future. US Brand Name. No dosage adjustment is required in elderly or in patients with mild to moderate renal dysfunction, and the risk of first-dose hypotension is low. The starting dose is 50 mg losartan/12.5 mg hydrochlorothiazide or 100 mg losartan/12.5 mg hydrochlorothiazide, taken once per day. This medicinal product does not require any special storage conditions. Dose adjustment is not usually necessary for the elderly. Overall, there was a dose-response. These results were confirmed during period II of the study where patients were randomized to continue losartan or placebo, after three weeks of treatment. Like other substances that directly affect the renin-angiotensin system, losartan has been shown to induce adverse reactions on the late fetal development, resulting in fetal death and malformations. If you have high blood pressure, you may not have any symptoms. Bradycardia could occur from parasympathetic (vagal) stimulation. Aortic and mitral valve stenosis, obstructive hypertrophic cardiomyopathy. Eating a healthy, balanced diet can help if you have high blood pressure. Measures are depending on the time of medicinal product intake and kind and severity of symptoms. The maximal antihypertensive effect is attained 3-6 weeks after initiation of therapy. Losartan has been evaluated in clinical studies as follows: - in a controlled clinical trial in > 3,000 adult patients 18 years of age and older for essential hypertension, - in a controlled clinical trial in 177 hypertensive paediatric patients 6 to 16 years of age, - in a controlled clinical trial in > 9,000 hypertensive patients 55 to 80 years of age with left ventricular hypertrophy (see LIFE Study, section 5.1), - in controlled clinical trials in > 7,700 adult patients with chronic heart failure (see ELITE I, ELITE II, and HEAAL study, section 5.1), - in a controlled clinical trial in > 1500 type 2 diabetic patients 31 years of age and older with proteinuria (see RENAAL study, section 5.1). There is no therapeutic experience with losartan effects after taking a combined contraceptive., genotoxicity and carcinogenic potential trimethoprim-containing products ), a medicine you must up. 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